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Tetracycline compounds of the invention wherein R 1 and R 2 are linked to form a ring can be synthesized by reacting the alkene to form a heterocycle such as a lactone or lactam (COT, imiquimod cream canada carefully 1876-1904), as shown in Scheme 8. Nonsteroidal anti-inflammatory drugs and potentially nephrotoxic medications should be avoided!
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Cephalosporins are grouped into "generations" based on their spectrum of antimicrobial activity? Similar methodology can be used to synthesize 9-position aryl derivatives?